November 4, 2020

Guanylate cyclase

Guanylate Cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. 1

Soluble guanylate cyclase (sGC) is an important transducing enzyme of cyclic guanosine monophosphate (cGMP) signaling pathway in striatum which has been considered as a potential target for the treatment of Parkinson’s disease.2

  2. Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson’s Disease