Guanylate Cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. 1
Soluble guanylate cyclase (sGC) is an important transducing enzyme of cyclic guanosine monophosphate (cGMP) signaling pathway in striatum which has been considered as a potential target for the treatment of Parkinson’s disease.2
- https://en.wikipedia.org/wiki/Guanylate_cyclase
- Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson’s Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642137/