November 4, 2020

GTPases

GTPases

 are an important target in human diseases such as Alzheimer’s disease (AD), cardiovascular, pulmonary, and neurological disorders, and cancers 1

Small GTPases are proteins that switch between the GDP- and GTP-bound forms with the help of guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). 2

  1. Rho GTPases as theapeutic targets in Alzheimer’s disease – https://alzres.biomedcentral.com/articles/10.1186/s13195-017-0320-4
  2. GTPases in Intracellular Trafficking: An Overview – NCBI – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058835/