GTPases are an important target in human diseases such as Alzheimer’s disease (AD), cardiovascular, pulmonary, and neurological disorders, and cancers 1
Small GTPases are proteins that switch between the GDP- and GTP-bound forms with the help of guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). 2
- Rho GTPases as theapeutic targets in Alzheimer’s disease – https://alzres.biomedcentral.com/articles/10.1186/s13195-017-0320-4
- GTPases in Intracellular Trafficking: An Overview – NCBI – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058835/
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